The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension-Reference-Cited by-同舟云学术

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Published:2019-11-12 Issue:607 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Morikawa Masato¹²³^ORCID,Mitani Yoshihide⁴,Holmborn Katarina⁵,Kato Taichi⁴^ORCID,Koinuma Daizo¹^ORCID,Maruyama Junko⁶,Vasilaki Eleftheria²³^ORCID,Sawada Hirofumi⁴⁶^ORCID,Kobayashi Mai¹,Ozawa Takayuki¹,Morishita Yasuyuki¹,Bessho Yasumasa⁷,Maeda Shingo⁸^ORCID,Ledin Johan⁵^ORCID,Aburatani Hiroyuki⁹^ORCID,Kageyama Ryoichiro⁷,Maruyama Kazuo⁶^ORCID,Heldin Carl-Henrik²³^ORCID,Miyazono Kohei¹²³^ORCID

Affiliation:

1. Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

2. Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, SE-751 23 Uppsala, Sweden.

3. Ludwig Institute for Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.

4. Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

5. Genome Engineering Zebrafish Facility, Science For Life Laboratory, Uppsala University, SE-752 36 Uppsala, Sweden.

6. Department of Anesthesiology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

7. Institute for Frontier Life and Medical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.

8. Department of Medical Joint Materials, Kagoshima University, Kagoshima, Kagoshima 890-8544, Japan.

9. Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Meguro-ku, Tokyo 153-8904, Japan.

Abstract

BMP signaling induces a transcription factor that may block pulmonary arterial hypertension from developing.

Funder

European Research Council

Japan Society for the Promotion of Science

Cancerfonden

Vetenskapsrådet

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference68 articles.

1. BMP signaling in vascular biology and dysfunction

2. Targeting BMP signalling in cardiovascular disease and anaemia

3. Bone morphogenetic protein receptors and signal transduction

4. Genome-wide mechanisms of Smad binding

5. ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

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