Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma-Reference-Cited by-同舟云学术

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

Published:2010-11-09 Issue:147 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Fan Qi-Wen¹²³⁴,Cheng Christine¹²³⁴,Hackett Chris¹²³⁴,Feldman Morri⁵⁶,Houseman Benjamin T.⁵⁶,Nicolaides Theodore¹²³⁴,Haas-Kogan Daphne³⁴,James C. David³,Oakes Scott A.⁴⁷,Debnath Jayanta⁴⁷,Shokat Kevan M.⁵⁶⁸,Weiss William A.¹²³⁴

Affiliation:

1. Department of Neurology, University of California, 1450 Third Street, MC0520, San Francisco, CA 94158–9001, USA.

2. Department of Pediatrics, University of California, San Francisco, CA 94158–9001, USA.

3. Neurological Surgery and Brain Tumor Research Center, University of California, San Francisco, CA 94158–9001, USA.

4. Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158–9001, USA.

5. Program in Chemistry and Chemical Biology, University of California, San Francisco, CA 94158–9001, USA.

6. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158–9001, USA.

7. Department of Pathology, University of California, San Francisco, CA 94158–9001, USA.

8. Howard Hughes Medical Institute, University of California, San Francisco, CA 94158–9001, USA.

Abstract

Combined inhibition of PI3K, mTOR, and autophagy promotes glioma cell death.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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