Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK-Reference-Cited by-同舟云学术

Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK

Published:2015-01-20 Issue:360 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Murray Phillip B.¹,Lax Irit¹,Reshetnyak Andrey¹,Ligon Gwenda F.²,Lillquist Jay S.²,Natoli Edward J.²,Shi Xiarong¹,Folta-Stogniew Ewa³,Gunel Murat⁴⁵,Alvarado Diego²,Schlessinger Joseph¹

Affiliation:

1. Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA.

2. Kolltan Pharmaceuticals, New Haven, CT 06520, USA.

3. Keck Foundation Biotechnology Resource Laboratory, Yale University, New Haven, CT 06520, USA.

4. Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA.

5. Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Heparin binds and activates the receptor tyrosine kinase ALK, which has no known ligand.

Funder

Kolltan Pharmaceuticals

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference20 articles.

1. The genetic landscape of high-risk neuroblastoma

2. Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology

3. Anaplastic Thyroid Cancers Harbor Novel Oncogenic Mutations of the ALK Gene

4. Midkine Binds to Anaplastic Lymphoma Kinase (ALK) and Acts as a Growth Factor for Different Cell Types

5. Identification of Anaplastic Lymphoma Kinase as a Receptor for the Growth Factor Pleiotrophin

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