Mouse redox histology using genetically encoded probes

Author:

Fujikawa Yuuta1,Roma Leticia P.1,Sobotta Mirko C.1,Rose Adam J.2,Diaz Mauricio Berriel23,Locatelli Giuseppe4,Breckwoldt Michael O.45,Misgeld Thomas567,Kerschensteiner Martin46,Herzig Stephan23,Müller-Decker Karin8,Dick Tobias P.1

Affiliation:

1. Division of Redox Regulation, DKFZ–ZMBH (German Cancer Research Center–Center for Molecular Biology of the University of Heidelberg) Alliance, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

2. Joint Division Molecular Metabolic Control, DKFZ-ZMBH Alliance, DKFZ Heidelberg, Center for Molecular Biology (ZMBH) and University Hospital, University of Heidelberg, 69120 Heidelberg, Germany.

3. Institute for Diabetes and Cancer (IDC) and Joint Heidelberg–IDC Translational Diabetes Program, Heidelberg University Hospital, Helmholtz Center Munich, 85764 Neuherberg, Germany.

4. Institute of Clinical Neuroimmunology, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.

5. Institute of Neuronal Cell Biology, Technical University of Munich, 80802 Munich, Germany.

6. Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.

7. German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany.

8. Core Facility Tumor Models, DKFZ, 69120 Heidelberg, Germany.

Abstract

A cryogenic chemical processing method maps the redox state at the cellular and subcellular level in tissue sections.

Funder

Deutsche Forschungsgemeinschaft

Federal Ministry of Education and Research

European Research Council

DFG

European Union's Seventh Framework Program

ERC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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