Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3ɛ-Reference-Cited by-同舟云学术

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3ɛ

Published:2009-08-11 Issue:83 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Martínez-Martín Nuria¹,Risueño Ruth M.¹,Morreale Antonio²,Zaldívar Irene¹,Fernández-Arenas Elena¹,Herranz Fernando²,Ortiz Angel R.²,Alarcón Balbino¹

Affiliation:

1. Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain.

2. Bioinformatics Unit, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, Madrid 28049, Spain.

Abstract

A mutant CD3ɛ subunit that cannot change conformation in response to ligand binding exerts dominant-negative inhibition of T cell responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

1. An evolutionary and structural perspective on T cell antigen receptor function

2. The T-cell receptor signalosome: a dynamic structure with expanding complexity

3. Crystal structure of a human CD3- / dimer in complex with a UCHT1 single-chain antibody fragment

4. Crystal structure of the human T cell receptor CD3 heterodimer complexed to the therapeutic mAb OKT3

5. Mechanisms Contributing to T Cell Receptor Signaling and Assembly Revealed by the Solution Structure of an Ectodomain Fragment of the CD3ϵγ Heterodimer

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