SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor-Reference-Cited by-同舟云学术

SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor

Published:2010-02-09 Issue:108 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sehat Bita¹,Tofigh Ali²,Lin Yingbo¹,Trocmé Eric¹,Liljedahl Ulrika³,Lagergren Jens²,Larsson Olle¹

Affiliation:

1. Department of Oncology and Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:04, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

2. KTH Royal Institute of Technology, Computational Biology, Stockholm Bioinformatics Centre, SE-100 44 Stockholm, Sweden.

3. Department of Medical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.

Abstract

Attachment of SUMO lets insulin-like growth factor receptors act as transcriptional regulators in the nucleus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference61 articles.

1. The IGF-I Receptor in Cancer Research

2. The Role of the Insulin-like Growth Factor System in Human Cancer

3. Nuclear localization of EGF receptor and its potential new role as a transcription factor

4. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

5. c-erbB-3

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