AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB-Reference-Cited by-同舟云学术

AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB

Published:2016-09-06 Issue:444 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Hornick Noah I.¹²³,Doron Ben¹²³,Abdelhamed Sherif¹²³,Huan Jianya¹²⁴,Harrington Christina A.⁴⁵,Shen Rongkun⁶⁷⁸,Cambronne Xiaolu A.⁷,Chakkaramakkil Verghese Santhosh¹²³,Kurre Peter¹²³⁴

Affiliation:

1. Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

2. Pediatric Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.

3. Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, OR 97239, USA.

4. Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

5. Integrated Genomics Laboratory, Oregon Health & Science University, Portland, OR 97239, USA.

6. Department of Biology, State University of New York, Brockport, NY 14420, USA.

7. Vollum Institute, Oregon Health & Science University, Portland, OR 97239, USA.

8. The College at Brockport, State University of New York, Brockport, NY 14420, USA.

Abstract

Exosomes shed from acute myeloid leukemia cells suppress the expression of a hematopoietic transcription factor in the bone marrow.

Funder

Hyundai Hope on Wheels Foundation

NIH

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference37 articles.

1. Anti-infective prophylaxis in pediatric patients with acute myeloid leukemia

2. Acute Myeloid Leukemia

3. Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia

4. Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

5. Acute myeloid leukemia does not deplete normal hematopoietic stem cells but induces cytopenias by impeding their differentiation

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