Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis

Author:

Sisti Flavia1ORCID,Wang Soujuan1,Brandt Stephanie L.12,Glosson-Byers Nicole1,Mayo Lindsey D.3ORCID,Son Young Min1,Sturgeon Sarah2,Filgueiras Luciano14ORCID,Jancar Sonia4ORCID,Wong Hector5ORCID,Dela Cruz Charles S.6,Andrews Nathaniel6ORCID,Alves-Filho Jose Carlos7,Cunha Fernando Q.7ORCID,Serezani C. Henrique12ORCID

Affiliation:

1. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

2. Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

3. Herman B Wells Center for Pediatric Research, Departments of Pediatrics and Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

4. Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.

5. Division of Critical Care Medicine, Cincinnati Children’s Hospital Medical Center and Cincinnati Children’s Hospital Research Foundation, Cincinnati, OH 45229, USA.

6. Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

7. Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil.

Abstract

Nuclear localization of the phosphatase PTEN prevents cytokine storm–mediated organ injury during sepsis.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

American Lung Association of Indiana

FAPESP

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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