TALK-1 channels control β cell endoplasmic reticulum Ca 2+ homeostasis-Reference-Cited by-同舟云学术

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TALK-1 channels control β cell endoplasmic reticulum Ca 2+ homeostasis

Published:2017-09-19 Issue:497 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Vierra Nicholas C.¹^ORCID,Dadi Prasanna K.¹,Milian Sarah C.¹^ORCID,Dickerson Matthew T.¹^ORCID,Jordan Kelli L.¹^ORCID,Gilon Patrick²,Jacobson David A.¹^ORCID

Affiliation:

1. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.

2. Pôle d’endocrinologie, diabète et nutrition, Institut de recherche expérimentale et clinique, Université catholique de Louvain, Brussels 1200, Belgium.

Abstract

An ER-localized K + channel could be targeted to suppress ER stress in diabetic pancreatic β cells.

Funder

American Diabetes Association

National Institute of Diabetes and Digestive and Kidney Diseases

Vanderbilt Diabetes Research and Training Center

Vanderbilt Molecular Endocrinology Training Program

Vanderbilt Molecular Endocrinology Training Program Grant

Vanderbilt Integrated Training in Engineering and Diabetes

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference88 articles.

1. Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

2. Calcium release channel RyR2 regulates insulin release and glucose homeostasis

3. The central role of calcium in the effects of cytokines on beta-cell function: Implications for type 1 and type 2 diabetes

4. Pancreatic and Duodenal Homeobox Protein 1 (Pdx-1) Maintains Endoplasmic Reticulum Calcium Levels through Transcriptional Regulation of Sarco-endoplasmic Reticulum Calcium ATPase 2b (SERCA2b) in the Islet β Cell

5. Defective glucose-dependent endoplasmic reticulum Ca2+ sequestration in diabetic mouse islets of Langerhans

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1. Purinergic Ca2+ Signaling as a Novel Mechanism of Drug Tolerance in BRAF-Mutant Melanoma;Cancers;2024-06-30

2. Disrupted Endoplasmic Reticulum Ca2+ Handling: A Harβinger of β-Cell Failure;Biology;2024-05-25

3. The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults;eLife;2024-05-03

4. KCNH6 is essential for insulin secretion by regulating intracellular ER Ca²⁺ store;The FASEB Journal;2024-02-16

5. TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet;Cell Reports;2024-01

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