Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner-Reference-Cited by-同舟云学术

Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner

Published:2018-03-20 Issue:522 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zheng Hong¹^ORCID,Yu Wen-Mei¹,Waclaw Ronald R.²^ORCID,Kontaridis Maria I.³^ORCID,Neel Benjamin G.⁴^ORCID,Qu Cheng-Kui¹^ORCID

Affiliation:

1. Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Children’s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30322, USA.

2. Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

3. Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

4. Laura and Isaac Perlmutter Cancer Center, New York University, New York, NY 10016, USA.

Abstract

The catalytic activity of the phosphatase SHP2 is required for the proper development of ependymal cells in the mouse.

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Child Health and Human Development

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference50 articles.

1. The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2. Protein tyrosine phosphatases in the JAK/STAT pathway

3. Crystal Structure of the Tyrosine Phosphatase SHP-2

4. Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2

5. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

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