Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake-Reference-Cited by-同舟云学术

Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake

Published:2016-05-31 Issue:430 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Wardman Jonathan H.¹,Gomes Ivone¹,Bobeck Erin N.¹,Stockert Jennifer A.¹,Kapoor Abhijeet²,Bisignano Paola²,Gupta Achla¹,Mezei Mihaly²,Kumar Sanjai³,Filizola Marta²,Devi Lakshmi A.¹

Affiliation:

1. Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

2. Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

3. Department of Chemistry and Biochemistry, Queens College, Flushing, NY 11367, USA.

Abstract

Stimulation of the receptor GPR171 with a small-molecule ligand results in hyperphagia and weight gain in mice.

Funder

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference54 articles.

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5. ProSAAS-Derived Peptides are Colocalized with Neuropeptide Y and Function as Neuropeptides in the Regulation of Food Intake

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