C-reactive protein promotes bone destruction in human myeloma through the CD32–p38 MAPK–Twist axis

Author:

Yang Jing12ORCID,Liu Zhiqiang23ORCID,Liu Huan2ORCID,He Jin2,Yang Jianling2,Lin Pei4,Wang Qiang5ORCID,Du Juan6ORCID,Ma Wencai2,Yin Zheng7ORCID,Davis Eric2ORCID,Orlowski Robert Z.2,Hou Jian6ORCID,Yi Qing5ORCID

Affiliation:

1. Guangzhou Key Laboratory of Translational Medicine on Malignant Tumor Treatment, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou 510095, China.

2. Department of Lymphoma/Myeloma, Division of Cancer Medicine, and the Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

3. Department of Physiology and Pathology, Tianjin Medical University, Tianjin 300070, China.

4. Department of Hematopathology, Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

5. Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

6. Department of Hematology, The Myeloma and Lymphoma Center, Changzheng Hospital, The Second Military Medical University, Shanghai 200085, China.

7. Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Houston, TX 77030, USA.

Abstract

Liver-secreted C-reactive protein is not just a biomarker of myeloma, it promotes myeloma-associated bone loss in patients.

Funder

American Cancer Society

National Cancer Institute

Leukemia Research Foundation

University of Texas MD Anderson Cancer Center

National Natural Science Foundation of China

American Society of Hematology

Multiple Myeloma Research Foundation

Leukemia and Lymphoma Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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