The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria-Reference-Cited by-同舟云学术

The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria

Published:2018-10-02 Issue:550 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Moral-Sanz Javier¹^ORCID,Lewis Sophronia A.¹^ORCID,MacMillan Sandy¹^ORCID,Ross Fiona A.²,Thomson Adrian³^ORCID,Viollet Benoit⁴⁵⁶^ORCID,Foretz Marc⁴⁵⁶^ORCID,Moran Carmel³^ORCID,Hardie D. Grahame²^ORCID,Evans A. Mark¹^ORCID

Affiliation:

1. Centre for Discovery Brain Sciences and Cardiovascular Science, College of Medicine and Veterinary Medicine, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK.

2. Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

3. Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.

4. Institut Cochin, INSERM U1016, Sorbonne Paris cité, 75014 Paris, France.

5. CNRS UMR 8104, Sorbonne Paris cité, 75014 Paris, France.

6. Université Paris Descartes, Sorbonne Paris cité, 75014 Paris, France.

Abstract

Perfusion-ventilation matching in the lungs requires AMPK-α1 and AMPK-α2 activation downstream of LKB1.

Funder

Wellcome Trust

British Heart Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference57 articles.

1. The Pulmonary Circulation1

2. Observations on the Pulmonary Arterial Blood Pressure in the Cat

3. Physiological aspects of high-altitude pulmonary edema

4. Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT);Galie N.;Eur. Heart J.,2009

5. Determination of the sensitive vascular sites from which hypoxia and hypercapnia elicit rises in pulmonary arterial pressure;Bergofsky E. H.;Fed. Proc.,1968

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