PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE 2 -Mediated Inhibition of Phagocytosis of Fungi-Reference-Cited by-同舟云学术

PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE 2 -Mediated Inhibition of Phagocytosis of Fungi

Published:2012-02-07 Issue:210 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Serezani C. Henrique¹,Kane Steve¹,Medeiros Alexandra I.²,Cornett Ashley M.¹,Kim Sang-Hoon³,Marques Mariana Morato⁴,Lee Sang-Pyo⁵,Lewis Casey¹,Bourdonnay Emilie¹,Ballinger Megan N.¹,White Eric S.¹,Peters-Golden Marc¹

Affiliation:

1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

2. Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University–UNESP, Araraquara 14801-902, Brazil.

3. Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Eulji University School of Medicine, Seoul 139-711, South Korea.

4. Department of Immunology, Institute of Biomedical Science IV, University of São Paulo, São Paulo 05508-000, Brazil.

5. Division of Allergy, Gachon University Gil Hospital, Incheon 405-760, South Korea.

Abstract

By promoting actin depolymerization, the protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference64 articles.

1. Bloodstream Infections Due to Candida Species: SENTRY Antimicrobial Surveillance Program in North America and Latin America, 1997-1998

2. Fungal respiratory disease

3. Deeply invasive candidiasis

4. Leukotriene B4Induces Release of Antimicrobial Peptides in Lungs of Virally Infected Mice

5. Pathogen Recognition by the Innate Immune System

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