Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives

Author:

Obacz Joanna12ORCID,Avril Tony12ORCID,Le Reste Pierre-Jean123ORCID,Urra Hery456ORCID,Quillien Véronique12,Hetz Claudio45678,Chevet Eric12ORCID

Affiliation:

1. INSERM U1242, Chemistry, Oncogenesis, Stress Signaling, Université de Rennes 1, Rennes 35000, France.

2. Centre de Lutte Contre le Cancer Eugène Marquis, Rennes 35042, France.

3. Department of Neurosurgery, University Hospital Pontchaillou, Rennes 35000, France.

4. Faculty of Medicine, Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.

5. Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.

6. Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, University of Chile, 1027 Independencia, P.O. Box 70086, Santiago, Chile.

7. Buck Institute for Research on Aging, Novato, CA 94945, USA.

8. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Abstract

Combined therapies targeting the unfolded protein stress response might be a way to treat glioblastomas.

Funder

French National Cancer Institute

la Ligue contre le Cancer

Fondo Nacional de Desarrollo Científico y Tecnológico

CONICYT

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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