The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells-Reference-Cited by-同舟云学术

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The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

Published:2012-09-25 Issue:243 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Putz Ulrich¹,Howitt Jason¹,Doan Anh¹,Goh Choo-Peng¹,Low Ley-Hian¹,Silke John²,Tan Seong-Seng¹

Affiliation:

1. Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria 3010, Australia.

2. Cell Signalling and Cell Death Laboratory, Walter and Eliza Hall Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.

Abstract

A tumor suppressor protein with lipid phosphatase activity is carried to target cells in microvesicles.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference59 articles.

1. PTEN and the PI3-Kinase Pathway in Cancer

2. The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

3. The lipid phosphatase activity of PTEN is critical for its tumor supressor function

4. The Role of the ErbB Family Members in Non–Small Cell Lung Cancers Sensitive to Epidermal Growth Factor Receptor Kinase Inhibitors: Fig. 1.

5. PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

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1. Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression;Developmental Cell;2024-08

2. Post-Translational Modification of PTEN Protein: Quantity and Activity;Oncology Reviews;2024-07-31

3. The emerging role of the exosomal proteins in neuroblastoma;Frontiers in Oncology;2024-06-19

4. Role of Exosomes in Cancer and Aptamer-Modified Exosomes as a Promising Platform for Cancer Targeted Therapy;Biological Procedures Online;2024-05-27

5. Integrated proteomic, phosphoproteomic, and N-glycoproteomic analyses of small extracellular vesicles from C2C12 myoblasts identify specific PTM patterns in ligand-receptor interactions;Cell Communication and Signaling;2024-05-16

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