Dynamic palmitoylation controls the microdomain localization of the DKK1 receptors CKAP4 and LRP6

Author:

Sada Ryota1ORCID,Kimura Hirokazu1,Fukata Yuko23ORCID,Fukata Masaki23ORCID,Yamamoto Hideki1,Kikuchi Akira1ORCID

Affiliation:

1. Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita 565-0871, Japan.

2. Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institute of Natural Sciences, Okazaki 444-8787, Japan.

3. Department of Physiological Sciences, School of Life Science, SOKENDAI, The Graduate University for Advanced Studies, Okazaki 444-8787, Japan.

Abstract

DKK1 stimulates depalmitoylation of its receptors CKAP4 and LRP6, causing their movement from lipid rafts.

Funder

Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care

Yasuda Memorial Foundation

Grants-in-Aid for Scientific Research (S)

Grants-in-Aid for Scientific Research (C)

Grants-in-Aid for Scientific Research for Young Scientists (Start-up)

Project for Cancer Research And Therapeutic Evolution (P-CREATE) to A.K. from the Japan Agency for Medical Research and development, AMED.

Grants-in-Aid for Scientific Research on Innovation Areas, ’’Organelle zone’’

Grants-in-Aid for Scientific Research on Innovation Areas, ’’Cell diverse’’

Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Reserch Initiatives, Osaka University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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