Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice-Reference-Cited by-同舟云学术

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

Published:2017-11-07 Issue:504 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Santini Emanuela¹²^ORCID,Huynh Thu N.¹^ORCID,Longo Francesco¹^ORCID,Koo So Yeon¹^ORCID,Mojica Edward¹^ORCID,D’Andrea Laura³,Bagni Claudia³⁴⁵⁶,Klann Eric¹^ORCID

Affiliation:

1. Center for Neural Science, New York University, New York, NY 10003, USA.

2. Department of Neurology, Columbia University, New York, NY 10032, USA.

3. Department of Biomedicine and Prevention, University of Rome “Tor Vergata,” 00133 Rome, Italy.

4. Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease, KU Leuven, 3000 Leuven, Belgium.

5. VIB Center for the Biology of Disease, 3000 Leuven, Belgium.

6. Department of Fundamental Neuroscience, University of Lausanne, 1005 Lausanne, Switzerland.

Abstract

Inhibiting the translation initiation factor eIF4E corrects neuronal behavioral phenotypes in a mouse model of fragile X syndrome.

Funder

National Institute of Neurological Disorders and Stroke

Congressionally Directed Medical Research Programs

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference96 articles.

1. A Decade of Molecular Studies of Fragile X Syndrome

2. Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

3. The translation of translational control by FMRP: therapeutic targets for FXS

4. From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome

5. A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome

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