A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation-Reference-Cited by-同舟云学术

A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation

Published:2021-08-03 Issue:694 Volume:14 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Ernst Orna¹^ORCID,Sun Jing¹,Lin Bin¹,Banoth Balaji²^ORCID,Dorrington Michael G.¹,Liang Jonathan¹³^ORCID,Schwarz Benjamin⁴^ORCID,Stromberg Kaitlin A.⁴^ORCID,Katz Samuel¹³,Vayttaden Sharat J.¹^ORCID,Bradfield Clinton J.¹^ORCID,Slepushkina Nadia⁵^ORCID,Rice Christopher M.⁶,Buehler Eugen⁵^ORCID,Khillan Jaspal S.⁷^ORCID,McVicar Daniel W.⁶,Bosio Catharine M.⁴,Bryant Clare E.³,Sutterwala Fayyaz S.²,Martin Scott E.⁵,Lal-Nag Madhu⁵^ORCID,Fraser Iain D. C.¹^ORCID

Affiliation:

1. Signaling Systems Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

2. Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

3. Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.

4. Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, USA.

5. The Trans-NIH RNAi Facility, National Center for Advancing Translational Sciences, NIH, Rockville, MD 20850, USA.

6. Laboratory of Cancer Immunometabolism, National Cancer Institute, NIH, Frederick, MD 21702, USA.

7. Mouse Genetics and Gene Modification Section, Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.

Abstract

The enzyme NDPK-D promotes changes in mitochondrial function that support inflammasome activation.

Funder

National Institutes of Health

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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