1. Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
2. Department of Pathology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
3. Department of Statistics, University of Kentucky, Lexington, KY 40536, USA.
4. Department of Biostatistics and Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.