Impaired α IIb β 3 Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1-Reference-Cited by-同舟云学术

Impaired α IIb β 3 Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1

Published:2010-01-05 Issue:103 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Elvers Margitta¹,Stegner David¹,Hagedorn Ina¹,Kleinschnitz Christoph²,Braun Attila¹,Kuijpers Marijke E. J.³,Boesl Michael⁴,Chen Qin⁵,Heemskerk Johan W. M.³,Stoll Guido²,Frohman Michael A.⁵,Nieswandt Bernhard¹

Affiliation:

1. University Clinic Würzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Würzburg, Josef-Schneider-Strasse 2, 97080 Würzburg, Germany.

2. Department of Neurology, University Clinic, 97080 Würzburg, Germany.

3. Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, 6200 MD Maastricht, the Netherlands.

4. Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany.

5. Department of Pharmacology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794–5140, USA.

Abstract

In the absence of PLD1, platelets do not form stable aggregates under high shear conditions.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference64 articles.

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3. Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

4. Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow

5. Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo

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