The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor-Reference-Cited by-同舟云学术

The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor

Published:2017-01-03 Issue:460 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Brand Toni M.¹^ORCID,Iida Mari¹,Corrigan Kelsey L.¹,Braverman Cara M.¹,Coan John P.¹,Flanigan Bailey G.¹,Stein Andrew P.¹,Salgia Ravi²,Rolff Jana³,Kimple Randall J.¹,Wheeler Deric L.¹^ORCID

Affiliation:

1. Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA.

2. Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA.

3. Experimental Pharmacology and Oncology Berlin-Buch GmbH, Robert-Roessle-Str. 10, 13125 Berlin, Germany.

Abstract

The kinase AXL promotes cetuximab resistance by promoting the nuclear accumulation of EGFR.

Funder

NIH National Center for Advancing Translational Sciences

American Cancer Society

U.S. Army Medical Research and Materiel Command

NIH/National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference76 articles.

1. The ERBB network: at last, cancer therapy meets systems biology

2. SnapShot: EGFR Signaling Pathway

3. Epidermal growth factor receptor targeting in cancer: A review of trends and strategies

4. Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations

5. Endocytosis and intracellular trafficking of ErbBs

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeting AXL in mesothelioma: From functional characterization to clinical implication;Critical Reviews in Oncology/Hematology;2023-08

2. The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer;Communications Biology;2023-06-22

3. AXL upregulates c‑Myc expression through AKT and ERK signaling pathways in breast cancers;Molecular and Clinical Oncology;2023-02-08

4. Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies;Critical Reviews in Oncology/Hematology;2022-06

5. AXL Receptor Tyrosine Kinase as a Promising Therapeutic Target Directing Multiple Aspects of Cancer Progression and Metastasis;Cancers;2022-01-18