Coupling Mechanism of a GPCR and a Heterotrimeric G Protein During Chemoattractant Gradient Sensing in Dictyostelium-Reference-Cited by-同舟云学术

Coupling Mechanism of a GPCR and a Heterotrimeric G Protein During Chemoattractant Gradient Sensing in Dictyostelium

Published:2010-09-28 Issue:141 Volume:3 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Xu Xuehua¹,Meckel Tobias¹,Brzostowski Joseph A.²,Yan Jianshe¹,Meier-Schellersheim Martin³,Jin Tian¹

Affiliation:

1. Chemotaxis Signal Section, National Institutes of Health, Rockville, MD 20852, USA.

2. Laboratory of Immunogenetics Imaging Facility, Laboratory of Immunogenetics, National Institutes of Health, Rockville, MD 20852, USA.

3. Program in Systems Immunology and Infectious Disease Modeling, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

Abstract

Imaging analyses and computer simulations suggest that a GPCR and its G protein associate only in the presence of ligand.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference44 articles.

1. How receptors talk to trimeric G proteins

2. G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

3. The structure and function of G-protein-coupled receptors

4. Chemotaxis, chemokine receptors and human disease

5. Mode of coupling between the β-adrenergic receptor and adenylate cyclase in turkey erythrocytes

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