Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes-Reference-Cited by-同舟云学术

Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes

Published:2019-02-19 Issue:569 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zurawski Zack¹²^ORCID,Thompson Gray Analisa D.¹^ORCID,Brady Lillian J.¹^ORCID,Page Brian²^ORCID,Church Emily²^ORCID,Harris Nicholas A.³^ORCID,Dohn Michael R.¹,Yim Yun Young¹^ORCID,Hyde Karren¹,Mortlock Douglas P.³,Jones Carrie K.¹⁴^ORCID,Winder Danny G.³,Alford Simon²^ORCID,Hamm Heidi E.¹^ORCID

Affiliation:

1. Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.

2. Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.

3. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.

4. Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.

Abstract

Genetic ablation of Gβγ-SNARE signaling produces stress- and depression-related behaviors.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference108 articles.

1. Modulation of neurotransmitter release by the second messenger-activated protein kinases: Implications for presynaptic plasticity

2. Neurotransmitters decrease the calcium component of sensory neurone action potentials

3. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence

4. PRESYNAPTIC RECEPTORS

5. Modulation of Ca2+ channels βγ G-protein py subunits

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