The C-Terminal SH3 Domain Contributes to the Intramolecular Inhibition of Vav Family Proteins-Reference-Cited by-同舟云学术

The C-Terminal SH3 Domain Contributes to the Intramolecular Inhibition of Vav Family Proteins

Published:2014-04-15 Issue:321 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Barreira María¹²,Fabbiano Salvatore¹²,Couceiro José R.¹²,Torreira Eva³,Martínez-Torrecuadrada Jorge L.⁴,Montoya Guillermo⁵,Llorca Oscar³,Bustelo Xosé R.¹²

Affiliation:

1. Centro de Investigación del Cáncer, Campus Unamuno, E37007 Salamanca, Spain.

2. Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC)–University of Salamanca, Campus Unamuno, E37007 Salamanca, Spain.

3. Centro de Investigaciones Biológicas, CSIC, 9 Ramiro de Maeztu Street, E28040 Madrid, Spain.

4. Biotechnology Programme, Centro Nacional de Investigaciones Oncológicas, 3 Melchor Fernández Almagro Street, E28029 Madrid, Spain.

5. Structural Biology and Biocomputing Programme, Centro Nacional de Investigaciones Oncológicas, E28029 Madrid, Spain.

Abstract

An intramolecular double-lock system prevents spurious activation of a protein involved in lymphocyte development and cancer.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference65 articles.

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2. Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

3. VAV proteins as signal integrators for multi-subunit immune-recognition receptors

4. X. R. Bustelo in Encyclopedia of Signaling Molecules S. Choy Ed. (Springer New York 2012) pp. 1963–1976.

5. Regulatory and Signaling Properties of the Vav Family

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