Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration-Reference-Cited by-同舟云学术

Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration

Published:2014-08-05 Issue:337 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Mooz Juliane¹²,Oberoi-Khanuja Tripat Kaur¹,Harms Gregory S.³,Wang Weiru⁴,Jaiswal Bijay S.⁵,Seshagiri Somasekar⁵,Tikkanen Ritva⁶,Rajalingam Krishnaraj¹²

Affiliation:

1. Cell death signalling group, Institute of Biochemistry II, Goethe University Medical School, Frankfurt 60590, Germany.

2. Institute for Immunology, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, Building 708, Mainz 55131, Germany.

3. Stark Learning Center, Department of Biology and Health Sciences, Wilkes University, Wilkes-Barre, Pennsylvania, PA 18766, USA.

4. Department of Protein Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

5. Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA.

6. Institute of Biochemistry, Medical Faculty, University of Giessen, Giessen 35392, Germany.

Abstract

Targeting the RAF kinase dimerization may overcome resistance to current RAF inhibitors and prevent cancer metastasis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference40 articles.

1. The RAF proteins take centre stage

2. Raf Family Kinases: Old Dogs Have Learned New Tricks

3. Targeting RAS signalling pathways in cancer therapy

4. Ras oncogenes and their downstream targets

5. Raf kinases: Oncogenesis and drug discovery

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