mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases-Reference-Cited by-同舟云学术

mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases

Published:2014-02-25 Issue:314 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Tang Huibin¹²,Inoki Ken³,Lee Myung¹²,Wright Erika¹²,Khuong Andy¹,Khuong Amanda¹,Sugiarto Sista¹,Garner Matthew¹,Paik Jihye⁴,DePinho Ronald A.⁵,Goldman Daniel⁶,Guan Kun-Liang⁷,Shrager Joseph B.¹²

Affiliation:

1. Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA.

3. Life Science Institute, Department of Molecular and Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

4. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY 10065, USA.

5. Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

6. Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.

7. Department of Pharmacology and Moores Cancer Center, University of California, San Diego, San Diego, CA 92103, USA.

Abstract

A kinase complex associated with cellular growth has an unexpected role in muscle atrophy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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