Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance

Author:

Wu Wei12ORCID,Shi Fubiao1ORCID,Liu Dianxin1,Ceddia Ryan P.1ORCID,Gaffin Robert3ORCID,Wei Wan1,Fang Huafeng1,Lewandowski E. Douglas3ORCID,Collins Sheila1ORCID

Affiliation:

1. Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL 32827, USA.

2. Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.

3. Cardiovascular Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL 32827, USA.

Abstract

Natriuretic peptide receptor C deficiency improves metabolism through signaling in adipose tissue, rather than in skeletal muscle.

Funder

China Scholarship Council

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference58 articles.

1. Mechanisms linking obesity to insulin resistance and type 2 diabetes

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3. New vistas for the treatment of obesity: Turning the tide against the leading cause of morbidity and cardiovascular mortality in the developed world;Lepor N. E.;Rev. Cardiovasc. Med.,2013

4. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

5. Unexpected evidence for active brown adipose tissue in adult humans

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