Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization-Reference-Cited by-同舟云学术

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

Published:2018-07-17 Issue:539 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Miess Elke¹^ORCID,Gondin Arisbel B.²^ORCID,Yousuf Arsalan³^ORCID,Steinborn Ralph¹^ORCID,Mösslein Nadja⁴^ORCID,Yang Yunshi⁴^ORCID,Göldner Martin⁴,Ruland Julia G.⁴,Bünemann Moritz⁴,Krasel Cornelius⁴^ORCID,Christie MacDonald J.³^ORCID,Halls Michelle L.²^ORCID,Schulz Stefan¹^ORCID,Canals Meritxell²^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, Jena University Hospital–Friedrich Schiller University Jena, D-07747 Jena, Germany.

2. Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Victoria 3052, Australia.

3. Discipline of Pharmacology, University of Sydney, New South Wales 2006, Australia.

4. Department of Pharmacology and Toxicology, Philipps-University Marburg, D-35043 Marburg, Germany.

Abstract

High-efficacy opioids enhance receptor desensitization due to rapid and sustained GRK2/β-arrestin interactions.

Funder

Deutsche Forschungsgemeinschaft

National Health and Medical Research Council of Australia

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference43 articles.

1. Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance

2. Increases in Drug and Opioid-Involved Overdose Deaths — United States, 2010–2015

3. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

4. Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

5. Morphine Side Effects in β-Arrestin 2 Knockout Mice

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