Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation-Reference-Cited by-同舟云学术

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

Published:2015-09-29 Issue:396 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Klysz Dorota¹,Tai Xuguang²,Robert Philippe A.¹³,Craveiro Marco¹,Cretenet Gaspard¹,Oburoglu Leal¹,Mongellaz Cédric¹,Floess Stefan⁴,Fritz Vanessa¹,Matias Maria I.¹,Yong Carmen¹⁵,Surh Natalie¹,Marie Julien C.⁶⁷,Huehn Jochen⁴,Zimmermann Valérie¹,Kinet Sandrina¹,Dardalhon Valérie¹,Taylor Naomi¹

Affiliation:

1. Institut de Génétique Moléculaire de Montpellier, CNRS, UMR 5535, Université de Montpellier, F-34293 Montpellier, France.

2. Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA.

3. Department of Systems Immunology, Braunschweig Integrated Centre of Systems Biology, 38124 Braunschweig, Germany.

4. Department of Experimental Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

5. Cancer Immunology Research Program, Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria 3010, Australia.

6. Cancer Research Center of Lyon, INSERM U1052, CNRS 5286, Université Lyon 1, 69373 Lyon cedex 03, France.

7. DKFZ German Cancer Research Center, 69121 Heidelberg, Germany.

Abstract

Altering the availability of nutrients shapes T cell differentiation and the immune response.

Funder

European Marie Curie fellowship (ATTACK)

University of Montpellier II

Ligue Contre le Cancer

Association de la Recherche contre le Cancer (ARC)

Portuguese Foundation for Science and Technology

Association Francaise contre les Myopathies (AFM)

Cancer Therapeutics CRC

Australian Postgraduate Award

NIH

CNRS

INSERM

European Community

CNRS-NIH International Laboratory

ARC

ANR

INCa

German Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference63 articles.

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2. Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

3. Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cells

4. The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis

5. IL-7–induced proliferation of recent thymic emigrants requires activation of the PI3K pathway

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