Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel-Reference-Cited by-同舟云学术

Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel

Published:2018-01-23 Issue:514 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zimova Lucie¹^ORCID,Sinica Viktor¹^ORCID,Kadkova Anna¹^ORCID,Vyklicka Lenka¹^ORCID,Zima Vlastimil²,Barvik Ivan²,Vlachova Viktorie¹^ORCID

Affiliation:

1. Department of Cellular Neurophysiology, Institute of Physiology Czech Academy of Sciences, 14220 Prague, Czech Republic.

2. Division of Biomolecular Physics, Institute of Physics, Faculty of Mathematics and Physics, Charles University, 12116 Prague, Czech Republic.

Abstract

A cavity in the ion channel TRPA1 coordinates electrophilic, voltage, and calcium sensitivity and might be targeted to treat pain and other disorders.

Funder

Czech Science Foundation

Grant Agency of Charles University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference54 articles.

1. ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures

2. The transient receptor potential channel TRPA1: from gene to pathophysiology

3. TRPA1

4. TRPA1 channels: molecular sentinels of cellular stress and tissue damage

5. Structure of the TRPA1 ion channel suggests regulatory mechanisms

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Dual role of transient receptor potential ankyrin 1 in respiratory and gastrointestinal physiology: From molecular mechanisms to therapeutic targets;Frontiers in Physiology;2024-07-03

2. Conservation of the cooling agent binding pocket within the TRPM subfamily;2024-05-21

3. Piezo channels in the intestinal tract;Frontiers in Physiology;2024-02-06

4. Protein dynamics underlying allosteric regulation;Current Opinion in Structural Biology;2024-02

5. Human Transient Receptor Potential Ankyrin 1 Channel: Structure, Function, and Physiology;Subcellular Biochemistry;2024