Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype-Reference-Cited by-同舟云学术

Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype

Published:2017-11-21 Issue:506 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Midgley Adam C.¹^ORCID,Oltean Sebastian²,Hascall Vincent³,Woods Emma L.¹,Steadman Robert¹,Phillips Aled O.¹,Meran Soma¹^ORCID

Affiliation:

1. Wales Kidney Research Unit, Systems Immunity University Research Institute, Division of Infection and Immunity, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.

2. Institute of Biomedical and Clinical Sciences, University of Exeter Medical School,Exeter EX1 2LU, UK.

3. Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Abstract

Hyaluronidase 2 displaces the splicing machinery to favor the production of an antifibrotic isoform of the cell surface protein CD44.

Funder

Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference32 articles.

1. The myofibroblast, a key cell in normal and pathological tissue repair

2. Fibroblasts and myofibroblasts in renal fibrosis

3. Hyaluronan Regulates Bone Morphogenetic Protein-7-dependent Prevention and Reversal of Myofibroblast Phenotype

4. Bone Morphogenetic Proteins and its Receptors; Therapeutic Targets in Cancer Progression and Bone Metastasis?

5. Involvement of Hyaluronan in Regulation of Fibroblast Phenotype

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