Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT-Reference-Cited by-同舟云学术

Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT

Published:2017-09-26 Issue:498 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Sukenik Sigalit¹,Frushicheva Maria P.²,Waknin-Lellouche Cecilia¹,Hallumi Enas¹,Ifrach Talia¹,Shalah Rose¹,Beach Dvora¹,Avidan Reuven¹,Oz Ilana¹,Libman Evgeny¹,Aronheim Ami³,Lewinson Oded⁴,Yablonski Deborah¹^ORCID

Affiliation:

1. Department of Immunology, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.

2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

3. Department of Cell Biology and Cancer Science, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.

4. Department of Biochemistry, Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, Haifa 3525433, Israel.

Abstract

Constitutive dimerization of an adaptor molecule enables it to selectively amplify signaling by binding cooperatively to signaling complexes downstream of antigen receptors.

Funder

Israel Science Foundation

State of Lower Saxony-Israel Collaborative Fund

Colleck Research Fund

The Russell Berrie Nanotechnology Institute

Cancer Research Institute Irvington Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference60 articles.

1. Proximal signaling events in FcɛRI-mediated mast cell activation