Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation-Reference-Cited by-同舟云学术

Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation

Published:2012-03-20 Issue:216 Volume:5 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Kim Wook¹,Lao Qizong¹,Shin Yu-Kyong¹,Carlson Olga D.¹,Lee Eun Kyung²,Gorospe Myriam¹,Kulkarni Rohit N.³,Egan Josephine M.¹

Affiliation:

1. National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

2. Department of Biochemistry, College of Medicine, Catholic University of Korea, Seoul 137-701, Republic of Korea.

3. Department of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

Abstract

Activation of cannabinoid 1 receptors prevents insulin receptors from promoting β-cell survival in the pancreas.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference57 articles.

1. The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

2. Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

3. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

4. Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

5. The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.

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