Phosphoproteomics of CD2 signaling reveals AMPK-dependent regulation of lytic granule polarization in cytotoxic T cells

Author:

Zurli Vanessa1ORCID,Montecchi Tommaso1,Heilig Raphael2ORCID,Poschke Isabel3ORCID,Volkmar Michael3ORCID,Wimmer Giuliana1,Boncompagni Gioia1,Turacchio Gabriele4,D’Elios Mario Milco5,Campoccia Giuseppe6,Resta Nicoletta7,Offringa Rienk38ORCID,Fischer Roman2ORCID,Acuto Oreste9,Baldari Cosima Tatiana1ORCID,Kabanova Anna1ORCID

Affiliation:

1. Department of Life Sciences, University of Siena, via Aldo Moro 2, Siena 53100, Italy.

2. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.

3. Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

4. Institute of Biochemistry and Cell Biology, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy.

5. Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, Florence 50134, Italy.

6. Department of Immune Hematology and Transfusion Medicine, University Hospital of Siena, viale Bracci 16, Siena 53100, Italy.

7. Medical Genetics Unit, Department of Biomedical Sciences and Human Oncology, University of Bari, Policlinico Hospital, Piazza Giulio Cesare 11, Bari 70124, Italy.

8. Department of Surgery, Heidelberg University Hospital, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany.

9. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

Abstract

CD2-stimulated AMPK activation mediates lytic granule organization in cytotoxic T cells.

Funder

Istituto Toscano Tumori

Associazione Italiana per la Ricerca sul Cancro

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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