Polycystin 2 regulates mitochondrial Ca 2+ signaling, bioenergetics, and dynamics through mitofusin 2-Reference-Cited by-同舟云学术

Polycystin 2 regulates mitochondrial Ca 2+ signaling, bioenergetics, and dynamics through mitofusin 2

Published:2019-05-07 Issue:580 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Kuo Ivana Y.¹^ORCID,Brill Allison L.²^ORCID,Lemos Fernanda O.¹,Jiang Jason Y.³⁴^ORCID,Falcone Jeffrey L.³⁴^ORCID,Kimmerling Erica P.⁵,Cai Yiqiang⁶,Dong Ke⁶^ORCID,Kaplan David L.⁵^ORCID,Wallace Darren P.⁷,Hofer Aldebaran M.³⁴,Ehrlich Barbara E.¹²^ORCID

Affiliation:

1. Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.

2. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA.

3. Department of Surgery, Harvard Medical School, Brigham and Women's Hospital, MA 02132, USA.

4. VA Boston Healthcare System, West Roxbury, MA 02132, USA.

5. Department of Biomedical Engineering, Tufts University. Medford, MA 02155, USA.

6. Department of Internal Medicine, Yale University School of Medicine. New Haven, CT 06510, USA.

7. Department of Medicine and the Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Abstract

Enhanced mitochondrial function enhances cyst formation in an inherited kidney disease caused by loss of polycystin 2.

Funder

NIH Office of the Director

National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Veterans Affairs

National Center for Advancing Translational Sciences

National Institute of Biomedical Imaging and Bioengineering

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference86 articles.

1. Role of calcium ions in regulation of mammalian intramitochondrial metabolism

2. Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

3. MAM: more than just a housekeeper

4. Structural and functional link between the mitochondrial network and the endoplasmic reticulum

5. Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis

Cited by 84 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A new perspective on liver diseases: focusing on the mitochondria-associated endoplasmic reticulum membranes;Pharmacological Research;2024-09

2. β-hydroxybutyrate recapitulates the beneficial effects of ketogenic metabolic therapy in polycystic kidney disease;iScience;2024-09

3. IP3R2 regulates apoptosis by Ca2+ transfer through mitochondria-ER contacts in hypoxic photoreceptor injury;Experimental Eye Research;2024-08

4. Unravelling the complexity of the mitochondrial Ca2+ uniporter: regulation, tissue specificity, and physiological implications;Cell Calcium;2024-07

5. Calcium signaling crosstalk between the endoplasmic reticulum and mitochondria, a new drug development strategies of kidney diseases;Biochemical Pharmacology;2024-07