Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in LymphocytesA presentation from the EMBO workshop “Visualizing Immune System Complexity,” Centre d'Immunologie Marseille-Luminy, Marseille, France, 15 to 17 January 2009.-Reference-Cited by-同舟云学术

Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in LymphocytesA presentation from the EMBO workshop “Visualizing Immune System Complexity,” Centre d'Immunologie Marseille-Luminy, Marseille, France, 15 to 17 January 2009.

Published:2009-04-14 Issue:66 Volume:2 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Chakraborty Arup K.¹²³,Das Jayajit¹⁴,Zikherman Julie⁵,Yang Ming¹,Govern Christopher C.¹,Ho Mary⁶⁷,Weiss Arthur⁵⁸,Roose Jeroen⁶

Affiliation:

1. Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

2. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

3. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

4. Present address: Battelle Center for Mathematical Medicine, Nationwide Children's Hospital and Department of Pediatrics, and Biophysics Graduate Program, Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA.

5. Division of Rheumatology, Department of Medicine, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA.

6. Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA.

7. Present address: Graduate School of Physical Therapy, Samuel Merritt University, 450 30th Street, Suite 2800, Oakland, CA 94609, USA.

8. Howard Hughes Medical Institute, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA.

Abstract

Simulations, theory, and experiments reveal a potential molecular mechanism for digital signaling and short-term molecular memory in lymphocytes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference11 articles.

1. Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses

2. Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

3. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes

4. Structural Analysis of Autoinhibition in the Ras Activator Son of Sevenless

5. Structural Evidence for Feedback Activation by Ras·GTP of the Ras-Specific Nucleotide Exchange Factor SOS

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