PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor-Reference-Cited by-同舟云学术

PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor

Published:2020-09-15 Issue:649 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Ambler Rachel¹^ORCID,Edmunds Grace L.¹^ORCID,Tan Sin Lih¹,Cirillo Silvia¹,Pernes Jane I.¹^ORCID,Ruan Xiongtao²^ORCID,Huete-Carrasco Jorge¹^ORCID,Wong Carissa C. W.¹,Lu Jiahe¹^ORCID,Ward Juma¹^ORCID,Toti Giulia¹,Hedges Alan J.¹,Dovedi Simon J.³^ORCID,Murphy Robert F.²⁴⁵^ORCID,Morgan David J.¹^ORCID,Wülfing Christoph¹^ORCID

Affiliation:

1. School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TD, UK.

2. Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

3. R&D Oncology, AstraZeneca, Granta Park, Cambridge CB21 6GH, UK.

4. Departments of Biological Sciences, Biomedical Engineering and Machine Learning, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

5. Freiburg Institute for Advanced Studies and Faculty of Biology, Albert Ludwig University of Freiburg, 79104 Freiburg, Germany.

Abstract

PD-1 signaling suppresses tumor-infiltrating lymphocytes by destabilizing their interactions with target tumor cells.

Funder

National Science Foundation

National Institutes of Health

AstraZeneca

Wellcome Trust

H2020 European Research Council

Biotechnology and Biological Sciences Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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