p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators-Reference-Cited by-同舟云学术

p53 is regulated by aerobic glycolysis in cancer cells by the CtBP family of NADH-dependent transcriptional regulators

Published:2020-05-05 Issue:630 Volume:13 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Birts Charles N.¹²^ORCID,Banerjee Arindam¹,Darley Matthew¹,Dunlop Charles R.¹^ORCID,Nelson Sarah¹,Nijjar Sharandip K.³,Parker Rachel¹^ORCID,West Jonathan¹²^ORCID,Tavassoli Ali²³^ORCID,Rose-Zerilli Matthew J. J.¹²,Blaydes Jeremy P.¹²^ORCID

Affiliation:

1. Cancer Sciences Unit, Faculty of Medicine, University of Southampton, SO16 6YD England, UK.

2. Institute for Life Sciences, University of Southampton, SO17 1BJ England, UK.

3. Chemistry, University of Southampton, SO17 1BJ England, UK.

Abstract

Increased glycolytic stress in cancer cells stimulates p53 production to maintain metabolic homeostasis.

Funder

Medical Research Council

Cancer Research UK

Breast Cancer Now

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference64 articles.

1. On the Origin of Cancer Cells

2. How cancer metabolism is tuned for proliferation and vulnerable to disruption

3. E. Mullarky L. C. Cantley Diverting glycolysis to combat oxidative stress in Innovative Medicine: Basic Research and Development K. Nakao N. Minato S. Uemoto Eds. (2015) pp. 3–23.

4. The Emerging Hallmarks of Cancer Metabolism

5. A. L. Lehninger D. L. Nelson M. M. Cox Principles of Biochemistry (Ed. 2 1992).

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