Small Molecule–Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease-Reference-Cited by-同舟云学术

Small Molecule–Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease

Published:2011-09-06 Issue:189 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Maiguel Dony¹,Faridi Mohd Hafeez¹,Wei Changli¹,Kuwano Yoshihiro²,Balla Keir M.³,Hernandez Dayami⁴,Barth Constantinos J.¹,Lugo Geanncarlo³,Donnelly Mary¹,Nayer Ali¹,Moita Luis F.⁵,Schürer Stephan⁶,Traver David³,Ruiz Phillip⁴,Vazquez-Padron Roberto I.⁷,Ley Klaus²,Reiser Jochen¹,Gupta Vineet¹⁸

Affiliation:

1. Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miami, FL 33136, USA.

2. Division of Inflammation Biology, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.

3. Department of Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA.

4. Division of Transplantation, Department of Surgery, University of Miami, Miami, FL 33136, USA.

5. Cell Biology of the Immune System Unit, Instituto de Medicina Molecular, Universidade de Lisboa, 1649-028 Lisboa, Portugal.

6. Center for Computational Studies, Department of Medicine, University of Miami, Miami, FL 33136, USA.

7. Division of Vascular Biology, Department of Surgery, University of Miami, Miami, FL 33136, USA.

8. Department of Biochemistry and Molecular Biology, University of Miami, Miami, FL 33136, USA.

Abstract

Drugs that activate integrins inhibit leukocyte recruitment to sites of inflammation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference82 articles.

1. Structure and function of the leukocyte adhesion molecules CD11/CD18

2. Getting to the site of inflammation: the leukocyte adhesion cascade updated

3. A Novel Role for the β2 Integrin CD11b/CD18 in Neutrophil Apoptosis: A Homeostatic Mechanism in Inflammation

4. The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor.

5. Inside-out integrin signalling

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