Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist-Reference-Cited by-同舟云学术

Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist

Published:2013-10-22 Issue:298 Volume:6 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Hennen Stephanie¹,Wang Haibo²,Peters Lucas¹,Merten Nicole¹,Simon Katharina¹,Spinrath Andreas¹,Blättermann Stefanie¹,Akkari Rhalid³,Schrage Ramona⁴,Schröder Ralf¹,Schulz Daniel¹,Vermeiren Celine⁵,Zimmermann Katrin⁶,Kehraus Stefan⁷,Drewke Christel¹,Pfeifer Alexander⁶⁸,König Gabriele M.⁷⁸,Mohr Klaus⁴⁸,Gillard Michel⁵,Müller Christa E.³⁸,Lu Q. Richard²,Gomeza Jesus¹,Kostenis Evi¹⁸

Affiliation:

1. Molecular, Cellular, and Pharmacobiology Section, Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.

2. Departments of Developmental Biology and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

3. Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, 53121 Bonn, Germany.

4. Pharmacology and Toxicology Section, Institute of Pharmacy, University of Bonn, 53121 Bonn, Germany.

5. CNS Research, UCB Pharma, 1420 Braine l’Alleud, Belgium.

6. Institute of Pharmacology and Toxicology, University of Bonn, 53121 Bonn, Germany.

7. Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany.

8. PharmaCenter, University of Bonn, 53119 Bonn, Germany.

Abstract

Activation of GPR17 prevents oligodendrocyte maturation and reveals that inhibiting GPR17 may be a therapeutic strategy to treat multiple sclerosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference71 articles.

1. Multiple sclerosis – candidate mechanisms underlying CNS atrophy

2. Remyelination in the CNS: from biology to therapy

3. Myelin Regeneration: A Recapitulation of Development?

4. Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis

5. Will the real multiple sclerosis please stand up?

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