Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to G i ProteinsA Presentation from the 1st International HEALING Meeting: Hh-Gli Signaling in Development, Regeneration and Disease, Kolymbari, Crete, 23 to 25 June 2011.-Reference-Cited by-同舟云学术

Sonic Hedgehog Activates the GTPases Rac1 and RhoA in a Gli-Independent Manner Through Coupling of Smoothened to G i ProteinsA Presentation from the 1st International HEALING Meeting: Hh-Gli Signaling in Development, Regeneration and Disease, Kolymbari, Crete, 23 to 25 June 2011.

Published:2011-11-22 Issue:200 Volume:4 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Polizio Ariel H.¹,Chinchilla Pilar¹,Chen Xiaolen¹,Manning David R.²,Riobo Natalia A.¹³

Affiliation:

1. Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

2. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

3. Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract

Smoothened signals through small G proteins in one type of noncanonical Hedgehog signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference15 articles.

1. Analysis of G Protein Activation in Sf9 and Mammalian Cells by Agonist-Promoted [35S]GTPγS Binding

2. Activation of heterotrimeric G proteins by Smoothened

3. Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins

4. Purmorphamine activates the Hedgehog pathway by targeting Smoothened

5. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

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