CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2-Reference-Cited by-同舟云学术

CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2

Published:2019-06-11 Issue:585 Volume:12 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Liu Jiao¹²^ORCID,Du Junxia³^ORCID,Wang Yun²⁴^ORCID

Affiliation:

1. Center of Medical and Health Analysis, Peking University Health Science Center, Beijing 100191, China.

2. Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, the Key Laboratory for Neuroscience of the Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.

3. College of Biological Science and Engineering, Xingtai University, Xingtai 054001, Hebei Province, China.

4. PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.

Abstract

CDK5 inhibits constitutive internalization of the nociceptor TRPV1 and contributes to inflammatory hyperalgesia.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of China

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference57 articles.