G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs-Reference-Cited by-同舟云学术

G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs

Published:2018-10-16 Issue:552 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Lorenzen Emily¹^ORCID,Ceraudo Emilie¹^ORCID,Berchiche Yamina A.¹^ORCID,Rico Carlos A.¹^ORCID,Fürstenberg Alexandre¹²^ORCID,Sakmar Thomas P.¹³^ORCID,Huber Thomas¹^ORCID

Affiliation:

1. Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY 10065, USA.

2. Department of Inorganic and Analytical Chemistry, University of Geneva, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland.

3. Department of Neurobiology, Care Sciences and Society, Division for Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 141 57 Huddinge, Sweden.

Abstract

Understanding how CCR5 signals through different G protein subtypes may lead to improved HIV drugs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference53 articles.

1. Fulfilling the Promise of "Biased" G Protein–Coupled Receptor Agonism

2. Biased ligands at G-protein-coupled receptors: promise and progress

3. How Ligands Illuminate GPCR Molecular Pharmacology

4. Targeting Chemokine Receptors in HIV: A Status Report

5. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

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