Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy-Reference-Cited by-同舟云学术

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

Published:2015-04-07 Issue:371 Volume:8 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

So Jonathan¹²,Pasculescu Adrian¹,Dai Anna Y.¹,Williton Kelly¹,James Andrew¹,Nguyen Vivian¹,Creixell Pau³,Schoof Erwin M.³,Sinclair John⁴,Barrios-Rodiles Miriam¹,Gu Jun¹,Krizus Aldis¹,Williams Ryan¹,Olhovsky Marina¹,Dennis James W.¹⁵,Wrana Jeffrey L.¹⁵,Linding Rune³⁶,Jorgensen Claus⁴,Pawson Tony¹²⁵,Colwill Karen¹

Affiliation:

1. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

2. Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

3. Cellular Signal Integration Group (C-SIG), Technical University of Denmark (DTU), DK-2800 Lyngby, Denmark.

4. Cell Communication Team, The Institute of Cancer Research, London SW3 6JB, UK.

5. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

6. Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH), DK-2200 Copenhagen, Denmark.

Abstract

Analysis of kinase signaling involved in TRAIL-induced cell death highlights potential targets for combination cancer therapy.

Funder

Canadian Institutes of Health Research

Ontario Research Fund GL2

Ontario Genomics Institute

CIHR

CR-UK Career Establishment Award

The Lundbeck Foundation

European Research Council

European Union';s Seventh Framework Programme

VKR-funded Instrument Center for Systems Proteomics

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference132 articles.

1. New insights into apoptosis signaling by Apo2L/TRAIL

2. TRAIL on trial: preclinical advances in cancer therapy

3. Accumulation of driver and passenger mutations during tumor progression

4. Mechanisms of caspase activation

5. Getting TRAIL back on track for cancer therapy

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