Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes-Reference-Cited by-同舟云学术

Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes

Published:2017-11-21 Issue:506 Volume:10 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Lyons James S.¹^ORCID,Joca Humberto C.²^ORCID,Law Robert A.³,Williams Katrina M.¹,Kerr Jaclyn P.⁴,Shi Guoli⁴,Khairallah Ramzi J.⁵^ORCID,Martin Stuart S.⁶,Konstantopoulos Konstantinos³,Ward Christopher W.⁴^ORCID,Stains Joseph P.¹^ORCID

Affiliation:

1. Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

2. Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

3. Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

4. Department of Orthopaedics, University of Maryland School of Nursing, Baltimore, MD 21201, USA.

5. Myologica, LLC, New Market, MD 21212, USA.

6. Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Abstract

Cytoskeleton stiffness, which is affected by the abundance of detyrosinated tubulin, regulates mechanosensitivity in osteocytes.

Funder

National Institute of General Medical Sciences

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference70 articles.

1. The Osteocyte: An Endocrine Cell … and More

2. Mechanosensation and transduction in osteocytes

3. Osteocytes: Master Orchestrators of Bone

4. Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

5. Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

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