Single-molecule diffusion-based estimation of ligand effects on G protein–coupled receptors-Reference-Cited by-同舟云学术

Single-molecule diffusion-based estimation of ligand effects on G protein–coupled receptors

Published:2018-09-18 Issue:548 Volume:11 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Yanagawa Masataka¹^ORCID,Hiroshima Michio¹²³,Togashi Yuichi²⁴⁵^ORCID,Abe Mitsuhiro¹,Yamashita Takahiro⁶,Shichida Yoshinori⁶⁷,Murata Masayuki⁸,Ueda Masahiro²⁹,Sako Yasushi¹^ORCID

Affiliation:

1. Cellular Informatics Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

2. Laboratory for Cell Signaling Dynamics, RIKEN Center for Biosystems Dynamics Research, 6-2-3, Furuedai, Suita, Osaka 565-0874, Japan.

3. Japan Science and Technology Agency (JST), Core Research for Evolutional Science and Technology (CREST), Saitama, Japan.

4. Research Center for the Mathematics on Chromatin Live Dynamics, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8526, Japan.

5. Cybermedia Center, Osaka University, 5-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.

6. Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.

7. Research Organization for Science and Technology, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan.

8. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3-8-1, Meguro-ku, Tokyo 153-8902, Japan.

9. Laboratory of Single Molecule Biology, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.

Abstract

Single-molecule tracking of GPCR diffusion within the plasma membrane reveals the type of ligand with which it interacts.

Funder

MEXT, Japan

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference50 articles.

1. The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints

2. GPCRdb: the G protein‐coupled receptor database – an introduction

3. A comprehensive map of molecular drug targets

4. Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

5. Tools for GPCR drug discovery

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