Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT-Reference-Cited by-同舟云学术

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

Author:

Lien Evan C.¹^ORCID,Ghisolfi Laura¹^ORCID,Geck Renee C.¹^ORCID,Asara John M.²³,Toker Alex¹²³⁴^ORCID

Affiliation:

1. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

2. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02215 MA, USA.

3. Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

4. Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Inhibition of the transporter xCT by oncogenic PI3K mutants contributes to methionine dependency in breast cancer cells.

Funder

National Science Foundation

National Institutes of Health

Damon Runyon Cancer Research Foundation

Ludwig Institute for Cancer Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference66 articles.

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