Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition-Reference-Cited by-同舟云学术

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition

Published:2016-10-18 Issue:450 Volume:9 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Zhang Jinwei¹,Deng Xianming²,Kahle Kristopher T.³

Affiliation:

1. MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

2. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China.

3. Department of Cellular and Molecular Physiology and Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA.

Abstract

Exploiting unique characteristics of the WNK-SPAK pathway may yield useful antihypertensive medications.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference15 articles.

1. Kinase Drug Discovery – What’s Next in the Field?

2. 25 Years of Small Molecular Weight Kinase Inhibitors: Potentials and Limitations

3. Crystal Structure of the Kinase Domain of WNK1, a Kinase that Causes a Hereditary Form of Hypertension

4. Small-molecule WNK inhibition regulates cardiovascular and renal function

5. Human Hypertension Caused by Mutations in WNK Kinases

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