Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations-Reference-Cited by-同舟云学术

Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations

Published:2014-12-02 Issue:354 Volume:7 Page:
ISSN:1945-0877
Container-title:Science Signaling
language:en
Short-container-title:Sci. Signal.

Author:

Littlefield Peter¹,Liu Lijun¹,Mysore Venkatesh²,Shan Yibing²,Shaw David E.²³,Jura Natalia¹⁴

Affiliation:

1. Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158, USA.

2. D. E. Shaw Research, New York, NY 10036, USA.

3. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

4. Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA.

Abstract

Cancer-associated mutations in the catalytically inactive receptor HER3 enhance its ability to activate other members of the human epidermal growth factor receptor family.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

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